Table 2. Significant Main and Interaction Effects in the Bilateral Amygdala.

	Left amygdala						Right amygdala
	Peak coordinate			Z-score	Cluster size	PFWE	Peak coordinate			Z-score	Cluster size	PFWE
	X	Y	Z				X	Y	Z
Placebo model
Main effect of task conditiona	−28	−4	−18	4.35	168	0.001	20	−4	−14	5.61	205	<0.001
Task × group	−26	−2	−22	3.15	47	0.046	28	−10	−14	2.63	26	0.187
Controls: fearful-angry>happy-neutral	−28	−2	−18	5.05	189	<0.001	–	–	–	–	–	–
PTSD: fearful-angry>happy-neutral	−20	−4	−14	2.16	30	0.359	–	–	–	–	–	–
Oxytocin model
Medication × group	−30	−4	−24	3.19	29	0.047	18	−6	−12	2.70	12	0.188
Controls: oxytocin>placebo	−30	0	−22	3.52	29	0.016	–	–	–	–	–	–
PTSD: placebo>oxytocin	−30	−2	−24	3.26	20	0.034	–	–	–	–	–	–

Significant main and interaction effects for the left and right amygdala region of interests (ROIs). Baseline differences between PTSD patients and controls, males and females and task conditions were tested within the placebo model. In addition, oxytocin (OT) administration effects were tested within the OT model. P_FWE-values <0.05 were considered significant. Peak voxel coordinates are given in MNI space.

^aMain effect of task condition: fearful-angry faces elicited more amygdala activity compared with happy-neutral faces.