Table 1. Participant Demographics and Clinical Characteristics.
|
Thalamic morphology (main group) |
Thalamic connectivity (subgroup) |
|||||||
|---|---|---|---|---|---|---|---|---|
| AN (n=28) | HC (n=22) | Test statistic (d.f.) | P-valuea | AN (n=15) | HC (n=16) | Test statistic (d.f.) | P-valuea | |
| Age (years) | 19.36±0.44 | 20.50±0.63 | t(48)=1.54 | 0.13 | 19.00±0.50 | 20.31±0.77 | t(29)=1.41 | 0.17 |
| IQ (estimated) | 106.10±1.45 | 108.30±2.68 | t(44)=0.77 | 0.44 | 103.30±2.13 | 106.60±3.28 | t(26)=0.86 | 0.40 |
| BMI (kg/m2) | 17.16±0.26 | 21.26±0.38 | t(48)=9.25 | <0.000 | 17.37±0.29 | 21.57±0.45 | t(29)=7.75 | <0.000 |
| Lowest lifetime BMI (kg/m2) | 15.17±0.26 | 15.23±0.39 | ||||||
| Age of onset (years) | 14.87±0.38 | 14.26±0.53 | ||||||
| Illness duration (months) | 53.82±7.16 | 56.87±9.96 | ||||||
| EDE (score) | 3.08±0.27 | 0.08±0.23 | t(48)=−9.80 | <0.000 | 3.23±0.38 | 0.07±0.03 | t(28)=−8.24 | <0.000 |
| Education (years) | 13.18±0.38 | 13.91±0.49 | t(48)=1.26 | 0.21 | 12.93±0.36 | 13.63±0.59 | t(29)=0.99 | 0.33 |
| SES | 4.3±0.4 | 4.1±0.4 | t(45)=0.4 | 0.68 | 3.2±0.5 | 4.5±0.6 | t(27)=1.7 | 0.11 |
| Race | 89% Caucasian | 68% Caucasian | χ2(1)=3.40 | 0.06 | 80% Caucasian | 69% Caucasian | χ2(1)=0.50 | 0.47 |
| Subtype | 11 Binge-Purge,17 Restricting | 8 Binge-Purge,7 Restricting | ||||||
Abbreviations: AN, anorexia nervosa; BMI, body mass index; EDE, Eating Disorder Examination Interview; HC, healthy control; IQ, full-scale IQ estimated by the Wechsler Test of Adult Reading (WTAR); SES, socioeconomic status. Data are presented as mean±SEM (see Supplementary Table S1 for scoring details).
a
Two-tailed in case of t-tests.
P-values in bold denote statistical significance ⩽0.05.