Table 1.
List of 43 Genes involved in PCOS with UNIPROT-ID, PDB-ID and chromosomal locations.
| Gene name | Locus | Organism | Uniprot ID | Accession number | PDB-ID |
|---|---|---|---|---|---|
| CYP11A-cytochrome P450 side-chain cleavage enzyme (Marker Locus: D15S520) | Chromosome 15: 74,367,990-74,368,179 | Homo Sapiens | P05108 | P05108 | 3N9Y |
| Sex hormone binding globulin | Chromosome 17: 7,613,946-7,633,383 | Homo Sapiens | P04278 | ABY68008 | 1D2S |
| Luteinizing hormone choriogonadotropin receptor | Chromosome 2: 48,708,770-48,723,514 | Homo Sapiens | P22888.4 | P22888 | 1LUT |
| Follicle-stimulating hormone receptor | Chromosome 2: 48,962,157-49,154,537 | Homo Sapiens | P23945 | AAB26480 | 1XUN |
| Mothers against decapentaplegic homolog 4 | Chromosome 18: 51,028,394-51,085,045 | Homo Sapiens | Q13485 | NP_005350 | 1DD1 |
| Leptin | Chromosome 7: 128,241,284-128,257,628 | Homo Sapiens | P41159 | AAH69452 | 1AX8 |
| Leptin receptor | Chromosome 1: 65,420,652-65,641,559 | Homo Sapiens | P48357 | AAB09673 | 3V6O |
| Inhibin beta-B | Chromosome 2: 120,346,143-120,351,808 | Homo Sapiens | P09529 | AAH30029 | – |
| Inhibin beta-A | Chromosome 7: 41,685,114-41,703,108 | Homo Sapiens | P08476 | AAH07858 | 1NYS |
| Inhibin A (gene symbol: INHA) | Chromosome 2: 219,569,162-219,575,713 | Homo Sapiens | P05111 | P05111 | – |
| Pro-opiomelanocortin (gene symbol: POMC) |
Chromosome 2: 25,160,853-25,168,903 | Homo Sapiens | P01189 | P01189 | – |
| Uncoupling protein 213 (gene symbol: UCP2 + 3) |
Chromosome 11: 73,974,667-73,983,307 | Homo Sapiens | P55851 | P55851 | – |
| Melanocortin 4 receptor | Chromosome 18: 60,371,110-60,372,775 | Homo Sapiens | P32245 | AAO92061 | 2IQP |
| Insulin-like growth factor I | Chromosome 12: 102,395,867-102,480,645 | Homo Sapiens | P05019 | CAA40342 | 1B9G |
| Insulin-like growth factor I receptor | Chromosome 15: 98,648,971-98,964,530 | Homo Sapiens | P08069 | P08069 | 1IGR |
| Insulin-like growth factor binding protein1 + 3 (gene symbol: IGFBP1 + 3) | Chromosome 7: 45,888,357-45,893,668 | Homo Sapiens | P08833 | P08833 | 1ZT3 |
| Insulin gene VNTR (gene symbol: INS VNTR) | Chromosome 11: 2,159,779-2,161,341 | Homo Sapiens | P01308 | P01308 | 1A7F |
| Insulin receptor (Marker Locus: INSR) |
Chromosome 19: 7,112,255-7,294,034 | Homo Sapiens | P06213 | AAA59452 | 1GAG |
| Insulin receptor (Marker Locus: D19S216) |
Chromosome 19: 4,903,080-4,962,154 | Homo Sapiens | Q96T88 | Q96T88 | 2FAZ |
| Insulin receptor (Marker Locus: D19S905) |
Chromosome 19: 7,595,902-7,618,304 | Homo Sapiens | Q9P1Y5.2 | Q9P1Y5 | – |
| Insulin receptor (Marker Locus: D19S884) |
Chromosome 19: 8,065,402-8,149,846 | Homo Sapiens | Q75N90 | Q75N90 | – |
| Insulin receptor (Marker Locus: D19S391) |
Chromosome 19: 8,520,790-8,577,577 | Homo Sapiens | O00160 | O00160 | – |
| Insulin receptor (Marker Locus: D19S906) |
Chromosome 19: 8,580,242-8,610,735 | Homo Sapiens | Q9H324.2 | Q9H324 | – |
| Insulin receptor (Marker Locus: D19S840) |
Chromosome 19: 13,906,201-13,930,879 | Homo Sapiens | Q6P1N0 | Q6P1N0 | – |
| Insulin receptor (Marker Locus: D19S212) |
Chromosome 19: 18,207,961-18,255,419 | Homo Sapiens | Q08493 | Q08493 | 1LXU |
| Insulin receptor (Marker locus: D19S410) |
Chromosome 19: 17,281,645-17,287,646 | Homo sapiens | Q8NAG6 | Q8NAG6 | – |
| Insulin receptor substrate 1 | Chromosome 2: 226,731,317-226,799,759 | Homo Sapiens | P35568 | NP_005535 | 1IRS |
| Peroxisome proliferator-activated receptor-gamma | Chromosome 3: 12,287,368-12,434,356 | Homo Sapiens | P37231 | P37231 | 1FM6 |
| Mothers against decapentaplegic homolog 4(gene symbol: MADH4) | Chromosome 18: 51,028,394-51,085,045 | Homo sapiens | Q13485 | Q13485.1 | 1DD1 |
| Androgen receptor (Marker Locus: AR) |
Chromosome X: 67,544,032-67,730,619 | Homo Sapiens | P10275 | P10275 | 1E3G |
| CYP11A-cytochrome P450 side-chain cleavage enzyme Marker Locus: (D15S519) |
Chromosome 15: 74,337,759-74,367,740 | Homo Sapiens | P05108 | P05108 | 3N9Y |
| CYP17-cytochrome P450 17a-hydroxylasey17,20-desmolase Marker Locus: (D10S192) |
Chromosome 10: 102,830,531-102,837,533 | Homo Sapiens | P05093 | P05093 | 2C17 |
| CYP19-cytochrome P450 aromatase Marker Locus: (CYP19) |
Chromosome 15: 51,208,057-51,338,610 | Homo Sapiens | P11511 | P11511 | 1TQA |
| 17 b-hydroxysteroid dehydrogenase, type I Marker Locus: (D17S934) |
Chromosome 17: 42,549,214-42,555,213 | Homo Sapiens | P14061 | P14061 | 1A27 |
| 17 b-hydroxysteroid dehydrogenase, type II Marker Locus: (HSD17B2) | Chromosome 16: 82,035,004-82,098,534 | Homo Sapiens | P37059 | P37059 | – |
| 17 b-hydroxysteroid dehydrogenase, type III Marker Locus: (D9S1809) | Chromosome 9: 96,235,306-96,302,152 | Homo Sapiens | P37058 | P37058 | – |
| 3 b-hydroxysteroid dehydrogenase, type I and II Marker Locus: (D1S514) | Chromosome 1: 119,507,198-119,515,054 | Homo Sapiens | P14060 | P14060 | – |
| Steroidogenic acute regulatory protein Marker Locus: (D8S1821) | Chromosome 8: 38,143,649-38,151,265 | Homo Sapiens | P49675 | P49675 | 1IMG |
| Activin receptor 1 Marker Locus: (D12S347) | Chromosome 10: 102,479,229-102,502,711 | Homo Sapiens | P61163 | P61163 | – |
| Activin receptor 2A Marker Locus: (D2S2335) |
Chromosome 2: 147,844,517-147,930,826 | Homo Sapiens | P27037 | P27037 | 3Q4T |
| Activin receptor 2B Marker Locus:(D3S1298) |
Chromosome 3: 38,453,851-38,493,142 | Homo Sapiens | Q13705 | Q13705 | 2H6U |
| Inhibin C Marker Locus: (D12S1691) | Chromosome 12, NC_000012.12 (57434685.57452062) | Homo Sapiens | P55103 | P55103 | – |
| Follistatin Marker Locus: (D5S474) | Chromosome 5: 53,480,409-53,487,134 | Homo Sapiens | P19883 | P19883 | – |