Table 4. ANC and platelet count changes during CC-486 treatment.
| CC-486 300 mg once daily: 14 days/cycle (n=28) | CC-486 300 mg once daily: 21 days/cycle (n=27) | |
|---|---|---|
| Neutrophils | ||
| ANC <0.5 × 109/l at baseline, n (%) | 4 (14) | 3 (11) |
| Recovered to ANC⩾0.5 × 109/l on study, n (%) | 2/4 (50) | 3/3 (100) |
| Study day of recovery, median (range) | 30.5 (8–53) | 15 (8–16) |
| ANC ⩾0.5 × 109/l at baseline, n (%) | 24 (86) | 24 (89) |
| ANC decrease to <0.5 × 109/l on study, n (%) | 13/24 (54) | 15/24 (63) |
| Recovered to ANC ⩾0.5 × 109/l on study, n (%) | 12/13 (92) | 13/15 (87) |
| Time to recoverya (days), median (range) | 14 (5–73) | 20 (6–37) |
| Platelets | ||
| Plt count <20 × 109/l at baseline, n (%) | 4 (14) | 1 (4) |
| Recovered to Plt count ⩾20 × 109/l on study, n (%) | 2/4 (50) | 1/1 (100) |
| Study day of recovery, median (range) | 8 (8–8) | 48 |
| Plt count ⩾20 × 109/l at baseline, n (%) | 24 (86) | 26 (96) |
| Plt count decrease to <20 × 109/l on study, n (%) | 7/24 (29) | 12/26 (46) |
| Recovered to Plt count ⩾20 × 109/l on study, n (%) | 7/7 (100) | 10/12 (83) |
| Time to recoverya (days), median (range) | 8 (1–21) | 13 (2–85) |
Abbreviations: ANC=absolute neutrophil count; Plt=platelet.
a
From the first recorded decrease below ANC or platelet threshold to first recorded increase above the respective threshold.