Skip to main content
. 2016 Jan 29;30(4):929–936. doi: 10.1038/leu.2015.313

Figure 5.

Figure 5

Comparison of the six-marker core MRD flow assay with the 4-CLR 4-tube MRD flow assay and ClonoSEQ HTS. Data from serial dilution studies (n=18) and from patient samples after FCR-based therapy (n=12) were analyzed using the harmonized 4-CLR ERIC panel, the six-marker core panel and ClonoSEQ high-throughput sequencing. (a) Comparison of the six-marker core MRD flow assay with the ERIC 4-tube 4-CLR panel: For log-transformed data above the LOQ, linearity=0.99, correlation coefficient Pearson R=1.00, average difference=−0.044 log, 95% limit of agreement ±0.17 log. (b) Comparison of the six-marker core MRD flow assay with ClonoSEQ HTS: For log-transformed data above the LOQ, linearity=0.89, correlation coefficient Pearson R=0.75, average difference=−0.12 log, 95% limit of agreement ±1.3 log.