Table 5.
Association of PSS with FSIQ and TOVA domains, with and without measurements from a highly influential MPS VI patient.
| Outcome | Covariate | Association with outcome (95% CI) with influential patient | P-value with influential patient | Association with outcome (95% CI) without influential patient | P-value without influential patient |
|---|---|---|---|---|---|
| FSIQ | MPS IA (per PSS point) | − 2.82 (− 4.46, − 1.18) | < 0.001 | − 2.81 (− 4.45, − 1.18) | < 0.001 |
| MPS II (per PSS point) | − 4.11 (− 11.17, 2.95) | 0.254 | − 4.11 (− 11.17, 2.95) | 0.254 | |
| MPS VI (per PSS point) | − 5.83 (− 7.82, − 3.83) | < 0.001 | − 5.52 (− 10.05, − 0.98) | 0.017 | |
| d prime | MPS IA (per PSS point) | 0.03 (− 1.99, 2.05) | 0.979 | 0.09 (− 1.92, 2.11) | 0.927 |
| MPS II (per PSS point) | 2.19 (− 3.11, 7.48) | 0.418 | 2.24 (− 3.08,7.55) | 0.409 | |
| MPS VI (per PSS point) | − 3.04 (− 5.64, − 0.43) | 0.022 | 1.11 (− 1.47, 3.68) | 0.400 | |
| Omission errors | MPS IA (per PSS point) | − 0.46 (− 3.73, 2.80) | 0.781 | − 0.33 (− 3.62, 2.96) | 0.843 |
| MPS II (per PSS point) | 0.29 (− 6.38, 6.95) | 0.933 | 0.40 (− 6.28, 7.08) | 0.906 | |
| MPS VI (per PSS point) | − 2.28 (− 7.29, 2.73) | 0.372 | 5.57(0.47, 10.68) | 0.032 | |
| Reaction time | MPS IA (per PSS point) | 0.73 (− 0.90, 2.36) | 0.380 | 0.85 (− 0.75, 2.44) | 0.297 |
| MPS II (per PSS point) | 0.16 (− 5.91, 6.22) | 0.960 | 0.26 (− 5.81, 6.32) | 0.933 | |
| MPS VI (per PSS point) | 0.50 (− 3.51, 4.52) | 0.806 | 7.51 (4.91, 10.12) | < 0.001 | |
| Variability | MPS IA (per PSS point) | 1.10 (− 1.58, 3.77) | 0.422 | 1.23 (− 1.49, 3.95) | 0.374 |
| MPS II (per PSS point) | 1.35 (− 6.57, 9.28) | 0.738 | 1.47 (− 6.45, 9.39) | 0.716 | |
| MPS VI (per PSS point) | − 0.38 (− 5.20, 4.45) | 0.878 | 7.72 (3.74, 11.70) | < 0.001 |