Figure 1. Histological quantitative analysis of BCM correlates with ¹¹¹In-exendin-3 uptake.

(A,B) Representative images of insulin positive areas in control (A) and alloxan treated (B) rats. (C) Bar chart displaying BCM (mg) (n = 5). (D) Graph displaying quantitative analysis of β-cell inter-lobular distribution (n = 4–5). (E) BCM (mg) was plotted against ¹¹¹In-exendin-3 uptake (kBq, kilobecquerels) as determined by SPECT (r² = 0.52, p = 8.13 × 10⁻⁰⁶). In (A–E) untreated rats are shown in black and alloxan-treated rats are shown in white. Data are shown as means ± SEM, where *p < 0.05, **p < 0.01 and ***p < 0.001 compared with the corresponding healthy group. Scale bar represents 100 μm.