Table 1.

Cardiac hypertrophy and oxidative status in SHR and WKY after melon concentrate administration

	WKY		SHR
	Untreated	Treated	Untreated	Treated
BW (g)	277±5	271±3	272±2	278±3
LVW (mg)	569±11	564±8	709±8*	657±8*§§
LVWI (mg HW/gBW)	2.06±0.02	2.08±0.02	2.61±0.03*	2.36±0.02*§
Cardiomyocyte diameter (µm)	17.8±0.6	17.6±0.7	22.4±0.6*	18.0±0.6§
Nitrotyrosine (% of stained area)	1.0±0.1	1.1±0.1	3.7±0.5**	2.1±0.3*§
SOD (% of untreated group)	100	113±3§	83±2*	99±2§
GPx (% of untreated group)	100	114±4§	86±3*	101±2§
CAT (% of untreated group)	100	119±6	102±3	96±7

Values are means±SEM. BW, body weight; LVW, left ventricle weight; LVWI, left ventricular weight index; SOD, superoxide dismutase; GPx, glutathione peroxidase; CAT, catalase.

SOD, GPx, and CAT protein expressions were standardized within membranes by expressing the density of each band of interest relative to that of GAPDH in the same lane. Results are then expressed as relative change from the corresponding untreated group (WKY or SHR) band intensity.

^*p<0.05

^**p<0.01 compared with untreated WKY

^§p<0.05

^§§p<0.01 effect of melon concentrate treatment, compared with the untreated group.