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. 2016 Apr 15;6:24548. doi: 10.1038/srep24548

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Copyright © 2016, Macmillan Publishers Limited

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(A) The effects of salbutamol on degree of paw swelling in AA rats. SD rats were immunized with CFA on day 0 and then administered salbutamol or MTX for 14 days, from d15 to d28. The paw swelling degree of AA rats was evaluated on d0, d7, d14, d21, d28, and d35. Data are expressed as the mean ± SD for 6 animals in each group. ^##P < 0.01 vs Normal Control; *P < 0.05 vs AA group. (B) The effects of salbutamol on the joint histopathology of AA rats. Arrows a represent synovial hyperplasia, arrows b represent inflammatory cell infiltration, and arrows c represent pannus formation and bone erosion. Data are expressed as the mean ± SD for 6 animals in each group. ^##P < 0.01 vs Normal control; *P < 0.05, **P < 0.01 vs AA group. (C) The effects of salbutamol on the proliferation of thymus and spleen lymphocytes. Data are expressed as the mean ± SD for 6 animals in each group. ^#P < 0.05 compared with control; *P < 0.05 compared with AA group. (D) The effects of salbutamol on the proliferation of FLSs. Data are expressed as the mean ± SD for 6 animals in each group. ^#P < 0.05 compared with control; *P < 0.05 compared with AA group.