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. 2016 Apr 15;6:24566. doi: 10.1038/srep24566

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Cy3-labeled Ago299-5p blocked GFP-LC3 puncta formation, and AM299-5p promoted puncta formation in Neuro-2a cells (n = 100). Scale bar = 25 μm. (b) Quantitative analysis of the experiments in panel (a) (mean ± SD of independent experiments, n = 4, *p < 0.05). (c) Representative TEM images of AVs in control and miR-299-5p/AM299-5p-overexpressing primary hippocampal neurons from AD mice. Scale bar = 2 μm.