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. 2016 Apr 15;6:24466. doi: 10.1038/srep24466

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Copyright © 2016, Macmillan Publishers Limited

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(A) Small RNA sequencing data of 1765 digestive cancer samples were collected from TCGA. Embryonic origin and number of samples of each digestive cancer were shown. (B–D) Principal component analyses were performed for (B) six major digestive cancers, (c) esophageal and gastric cancers, and (D) seven reclassified digestive cancers. (E) Hierarchical clustering of all tumor samples was performed using expression profiles of 34 random forest-selected miRNAs. CAC, colon adenocarcinoma; RAC, rectal adenocarcinoma; GAC, gastric adenocarcinoma; EAC, esophageal adenocarcinoma; ESCC, esophageal squamous cell carcinoma; EWOS, esophageal cancer not otherwise specified; PAC, pancreatic adenocarcinoma; HCC, hepatocellular carcinoma.