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. 2016 Apr 15;6:24466. doi: 10.1038/srep24466

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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miRNAs associated with disease progression in colon adenocarcinoma (A) Principal component analysis identified miRNA expression pattern in colon adenocarcinomas with disease progression was different from those with complete remission. (B) Random forest was used to select miRNAs with greatest contribution to disease status classification. (C) A formula was constructed to calculate the ∆s score to predict the likelihood of disease progression. (D) Receiver-operating characteristic curve was used to evaluate the performance of the constructed formula.