Table 2.

Results of Univariate and of Multivariate Analysis of Prognostic Factors with Survival

Parameter	Hazard ratio	Confidence interval (95%)	Significance P
Univariate analysis
Albumin < 35 g/l	0.849	0.527–1.367	0.500
β2‐Microglobulin >5.5 g/l	2.146	1.340–3.436	0.001
ISS Stage (I vs. II vs. III)	1.554	1.177–2.051	0.002
Creatinine >2 mg/dl	1.115	0.485–2.560	0.798
LDH > 250 U/l	1.538	0.794–2.981	0.202
Response ≥ VGPR	1.757	1.147–2.692	0.010
Hemoglobin ≤ 10 g/dl	1.864	1.059–3.282	0.031
Calcium > 10.5 mg/dl (>2.6 mmol/l)	3.239	1.599–6.559	0.001
FLC ratio <0.03 or >32	1.018	0.677–1.531	0.932
HLC ratio <0.022 or > 45	1.712	1.135–2.583	0.010
HLC matched pair suppression <LLN	0.826	0.468–1.460	0.508
HLC matched pair suppression >50%	1.581	1.026–2.434	0.038
Noninvolved isotype suppression <LLN	0.994	0.754–1.312	0.981
Noninvolved isotype suppression >50%	0.932	0.729–1.193	0.811
Risk of FISH cytogenetics (90 patients)	2.131	1.189–3.819	0.009
Multivariate analysis
β2‐Microglobulin >5.5 g/l	1.389	0.669–2.884	0.378
ISS stage (I vs. II vs. III)	1.526	0.890–2.614	0.124
Response > VGPR	1.853	1.140–3.012	0.013
Hemoglobin > 10 g/dl	1.502	0.760–2.967	0.242
Calcium > 10.5 mg/dl (>2.6 mmol/l)	2.460	0.997–6.068	0.051
HLC ratio <0.022 or > 45	1.721	0.885–3.345	0.110
HLC matched pair suppression >50%	2.553	1.214–5.367	0.013