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. 2015 Aug 25;54(11):668–680. doi: 10.1002/gcc.22277

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© 2015 The Authors. Genes, Chromosomes & Cancer Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Overall survival (OS) analysis of CLL patients using the qChip®Hemo array. (A) Patients with 17p loss had a significantly shorter OS compared with patients without the 17p deletion. (B) Patients with 17p deletion detected by array had shorter OS compared with patients with 17p deletion detected only by FISH (10–17% cells in all cases), and patients without 17p deletion. (C) Patients with chromothripsis show significantly shorter OS compared with cases without. (D) Kaplan–Meier plot of OS of CLL patients according to increasing number of CNAs (0–3, vs. 4–6 vs. >6 alterations). (*P < 0.05; **P < 0.01; ***P < 0.001). CT, chromothripsis; D, deceased; N, number; WT, wild‐type (not deleted). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]