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Surviving anterior horn cells in C9orf72 associated motor neurone disease show skein‐like or more rounded, solid neuronal cytoplasmic inclusions that are both TDP‐43 (a) and p62 (b) positive. Small, specular cytoplasmic inclusions immunopositive for poly‐GA protein are only rarely present (c). Neuronal nuclei are immunopositive for poly‐PR protein (d). Immunoperoxidase – haematoxylin × 40 microscope objective magnification.
