Table A9.

Genetic variants located in PCSK9 gene region on chromosome 1 used in applied example from main paper: rsid, position (hg18), coding and non‐coding alleles, frequency of the coding allele, beta‐coefficient for association with LDL‐c with SE taken from GLGC, beta‐coefficient for association with CHD risk taken from CARDIoGRAM.

rsid	Position	Coding/non‐coding allele	Coding allele frequency	Association with LDL‐c (SE)	Association with CHD risk (SE)
rs1887552	55 260 222	A/T	0.29	0.037 (0.006)	0.018 (0.017)
rs11588151	55 260 236	A/G	0.81	0.059 (0.008)	0.072 (0.024)
rs9436961	55 261 419	T/A	0.27	0.046 (0.006)	0.019 (0.017)
rs2479418	55 267 465	G/A	0.49	0.018 (0.005)	0.033 (0.014)
rs2479417	55 268 332	T/C	0.35	0.017 (0.006)	0.002 (0.015)
rs2495497	55 268 583	T/C	0.12	0.035 (0.008)	0.003 (0.023)
rs11206510	55 268 627	T/C	0.78	0.083 (0.005)	0.080 (0.023)
rs17192725	55 268 719	A/G	0.07	0.048 (0.011)	0.046 (0.039)
rs17111490	55 268 764	T/C	0.07	0.002 (0.014)	−0.042 (0.043)
rs2094470	55 269 890	C/T	0.10	0.036 (0.011)	0.048 (0.028)

The primary SNP (rs11206510) is displayed in italics.

LDL‐c, low‐density lipoprotein cholesterol; SE, standard error; GLGC, Global Lipids Genetics Consortium; CHD, coronary heart disease; SNP, single nucleotide polymorphism.