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. 2016 Apr 15;6:24578. doi: 10.1038/srep24578

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Hematoxylin and eosin-stained sections of hyperplastic mesothelium and various malignant pleural mesothelioma subtypes, the (b) fractal dimension and (c) lacunarity of hyperplastic/benign, biphasic and epithelioid tumor samples was calculated using the FracLac ImageJ plug-in. Significant differences were detected between hyperplasia/benign control tissues and the biphasic and epithelioid subtypes, p ≤ 0.001. No significant different was detected between the biphasic and epithelioid subtypes. Results were analyzed via ANOVA with Tukey post-test. and are shown as the mean and SEM of each subtype.