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. 2015 Mar 13;77(5):760–774. doi: 10.1002/ana.24376

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© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Voxel‐based morphometry (VBM) results: differences between patient outcome groups. (A) The single cluster of voxels (yellow–orange) significantly different when patient outcome groups were directly compared, which corresponded to regional thalamic atrophy in patients with persistent postoperative seizures. (B) Quantification of mean gray matter volume within 4 thalamic a priori regions of interest revealed that ipsilateral medial dorsal and pulvinar, and contralateral medial dorsal regions were significantly atrophic in patients with persistent postoperative seizures relative to those rendered seizure free. CL, contralateral; IL, ipsilateral; ILAE = International League Against Epilepsy; SPM = Statistical Parametric Mapping. *p < 0.05, **p < 0.01. [Color figure can be viewed in the online issue, which is available at www.annalsofneurology.org.]