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. 2015 Dec 2;17(1):53–65. doi: 10.1111/tra.12341

Figure 7.

TRA-12341-FIG-0007-c

Regulation of VEGFR2 trafficking, signaling and proteolysis by USP8. Sustained VEGFR2 residence and ubiquitination in early endosomes leads to proteolysis that generates 160 and 120 kDa VEGFR2 fragments in USP8‐depleted cells. The 160 kDa fragment remains ubiquitinated and both VEGFR2 cleavage products accumulate in early endosomes due to an indirect effect of USP8 depletion on the ESCRT‐0 trafficking machinery. Both reduced de‐ubiquitination and enhanced proteolysis of accumulated VEGFR2 down‐regulate endosome‐linked signal transduction.