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. 2015 Jul 29;33(10):3006–3016. doi: 10.1002/stem.2095

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© 2015 The Authors. STEM CELLS Published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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MSC transplantation results in LCN2 production and STAT3 and ERK activation in retinal Muller glia. Immunostaining and Western blot confirming activation of (A) JAK STAT cascade, (B) MAPK cascade, and (C) LCN2 in retinal Muller glia following MSC transplantation. Error bars represent SEM, *, p < .05; **, p < .01; ***, p < .001, one‐way ANOVA test with Tukey's correction. Abbreviations: GFAP, glial fibrillary acidic protein; GFP, green fluorescent protein; INL, inner nuclear layer; MSC, mesenchymal stem cell; ONL, outer nuclear layer; PBS, phosphate buffered saline; RGCL, retinal ganglion cell layer.