Table 1.
Characteristics of the study groups
| Parameter | Baltic male cohort study group (n = 986) | Estonian idiopathic infertility group (n = 607) | ||
|---|---|---|---|---|
| Mean ± SD | Median (25–75th percentile) | Mean ± SD | Median (25–75th percentile) | |
| A. General characteristics | ||||
| Age (years) | 20.1 ± 2.1 | 19.8 (18.5–21.5) | 35.1 ± 5.9 | 30.7 (27.1–34.9) |
| BMI | 22.4 ± 2.6 | 22.1 (20.7–23.6) | 26.8 ± 4.5a | 26.0 (23.7–29.3) |
| Abstinence period (hours) | 107.7 ± 63.1 | 86.0 (63.0–134.0) | 75.3 ± 44.8 | 72.0 (48.0–96.0) |
| Total testes volume (mL) | 49.1 ± 10.4 | 50.0 (41.0–55.0) | 40.2 ± 10.2 | 40.0 (34.0–47.0) |
| Sperm concentration (106/mL) | 80.7 ± 72.1 | 63.3 (34.7–105.8) | 8.0 ± 5.9 | 7.0 (2.6–13.0) |
| B. Genotyping data of V‐LH (Trp8Arg, rs1800447) | ||||
| Allele frequencies, % (number of chromosomes) | ||||
| A | 89.0 (1756) | 90.7 (1101) | ||
| G | 11.0 (216) | 9.3 (113) | ||
| Genotype frequencies, % (number of genotype carriers)b | ||||
| A/A | 79.1 (780) | 82.4 (500) | ||
| A/G | 19.9 (196) | 16.6 (101) | ||
| G/G | 1.0 (10) | 1.0 (6) | ||
| χ2 test | p = 0.27c | |||
a
Data for BMI available for 318 patients of the Estonian idiopathic infertility group.
b
Hardy–Weinberg Equilibrium test in Baltic male cohort and Estonian idiopathic infertility group, p = 0.55 and p = 0.72, respectively.
c
p‐value from Chi‐squared test for differences in V‐LH genotype distribution between Estonian idiopathic infertility group and Baltic male cohort.