Table 2.
Correlations between γδ, CD4+ and CD8+ T, and FoxP3+ cell Expression and Clinicopathologic Characteristics in Breast Cancer Patients.
| γδ T (n=46) | P | FoxP3 (n=81) | P | CD4 (n=81) | P | CD8 (n=81) | P | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤9 | >9 | ≤12 | >12 | ≤16 | >16 | ≤13 | >13 | |||||
| Age | ||||||||||||
| <60 years | 12 | 11 | 23 | 18 | 23 | 18 | 14 | 25 | ||||
| ≥60 years | 11 | 12 | 0.878 | 21 | 18 | 0.982 | 24 | 15 | 0.789 | 21 | 20 | 0.247 |
|
| ||||||||||||
| Tumor stage | ||||||||||||
| I | 17 | 0 | 24 | 6 | 27 | 3 | 7 | 23 | ||||
| II | 6 | 10 | 18 | 12 | 15 | 15 | 15 | 15 | ||||
| III | 1 | 12 | 1.19×10−6 | 3 | 18 | 1.69×10−5 | 6 | 15 | 2.75×10−5 | 13 | 8 | 0.015 |
|
| ||||||||||||
| Tumor size | ||||||||||||
| <2.1 cm | 15 | 8 | 27 | 14 | 30 | 11 | 15 | 24 | ||||
| ≥2.1 cm | 9 | 14 | 0.101 | 17 | 22 | 0.075 | 17 | 22 | 0.014 | 20 | 21 | 0.481 |
|
| ||||||||||||
| Nodal status | ||||||||||||
| Negative | 21 | 4 | 30 | 12 | 32 | 10 | 11 | 31 | ||||
| positive | 3 | 18 | 9.94×10−6 | 15 | 24 | 0.006 | 16 | 23 | 0.003 | 24 | 15 | 2.84×10−3 |
|
| ||||||||||||
| ER status | ||||||||||||
| Negative | 8 | 3 | 12 | 11 | 11 | 12 | 7 | 16 | ||||
| Positive | 16 | 19 | 0.223 | 33 | 25 | 0.890 | 37 | 21 | 0.285 | 28 | 30 | 0.225 |
|
| ||||||||||||
| HER2 | ||||||||||||
| High | 2 | 12 | 10 | 12 | 13 | 9 | 11 | 11 | ||||
| Low | 21 | 7 | 29 | 14 | 28 | 15 | 15 | 28 | ||||
| Negative | 2 | 2 | 0.002 | 3 | 7 | 0.049 | 2 | 8 | 0.033 | 6 | 4 | 0.249 |
|
| ||||||||||||
| Relapse-free Survival | ||||||||||||
| No-recurrance | 24 | 8 | 39 | 16 | 38 | 17 | 12 | 35 | ||||
| Recurrence | 0 | 14 | 1.27×10−5 | 3 | 14 | 3.04×10−4 | 7 | 10 | 0.073 | 15 | 19 | 2.67×10−5 |
|
| ||||||||||||
| Overall Survival | ||||||||||||
| Alive | 24 | 7 | 40 | 16 | 37 | 19 | 17 | 39 | ||||
| Died | 0 | 15 | 3.97×10−6 | 5 | 20 | 4.89×10−5 | 11 | 14 | 0.105 | 18 | 7 | 1.14 ×10−3 |
Note: Evaluated by χ2 test. Abbreviations: ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; FoxP3, forkhead box protein P3.