Table 2.

Top allelic associations to VTE risk among AAs

Chr	SNP	Nearby genes	MA	Discovery cohort					Replication cohort				Meta-analysis
				IM	MAF cases	MAF controls	OR (95% CI)	P*	MAF cases	MAF controls	OR (95% CI)	P*	P
4	rs62322307	ATOH1	T	0.94	0.15	0.06	2.79 (1.8-4.3)	2.25 × 10−7	ND	ND	ND	ND	NA
7	rs73692310	IGFBP3	T	0.78	0.15	0.05	3.04 (2.0-4.7)	1.73 × 10−9	0.09	0.07	1.27 (0.4-2.7)	.60	2.48 × 10−8
18	rs58952918	NA	A	0.90	0.17	0.08	2.48 (1.7-3.7)	1.07 × 10−8	NT	NT	NT	NT	NA
18	rs28496996	NA	G	0.90	0.17	0.08	2.44 (1.6-3.6)	1.13 × 10−8	0.13	0.11	1.34 (0.6-2.6)	.45	6.37 × 10−8
20	rs2144940	THBD, CD93	C	0.97	0.31	0.17	2.18 (1.6-2.9)	3.52 × 10−7	0.35	0.21	1.89 (1.1-3.3)	.016	1.88 × 10−8
20	rs2567617	THBD, CD93	G	0.98	0.31	0.17	2.17 (1.6-2.9)	4.01 × 10−7	NT	NT	NT	NT	NA
20	rs1998081	THBD, CD93	T	NA	0.27	0.14	2.28 (1.6-3.1)	5.17 × 10−7	0.30	0.18	1.94 (1.1-3.5)	.016	4.62 × 10−8

SNP rs1998081 was genotyped.

Chr, chromosome; IM, infometric (takes a value between 0 and 1, whereby values near 1 indicate that an SNP has been imputed with high certainty); MA, minor allele; MAF, minor allele frequency; NA, not applicable; ND, not determined due to failed assay; NT, not tested due to high LD.

^*Age adjusted.