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. 2016 Apr 14;9:25. doi: 10.1186/s13048-016-0234-y

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© Abed et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The effect of BH3 mimetic combinations on caspase 3/7 activity. The indicated cells were exposed to 66 μM of carboplatin in all cell lines or the indicated BH3 mimetic (as described in Methods) for 48 h (24 h for Ovcar-4) and the caspase activity then measured. The results (mean ± S.D., n = 3) were expressed as a fraction of the caspase activity measured in cells treated with carboplatin alone and were normalized to surviving cell number estimated by staining with SRB. The results were significantly different where indicated (*, P < 0.05, paired t-test) from the expected effect of the drug combination indicated with an horizontal solid line and calculated from the Bliss independence criterion and the effect of the single agents