Table 8.
Comparison of various comorbidities in females with CDKL5 disorder (n = 143) and Rett syndrome (n = 321)
| Comorbidity type | Rett syndromea | CDKL5 disorder | RR (95 % CI) | p value |
|---|---|---|---|---|
| n (%) | n (%) | |||
| GI health | ||||
| Any GI Problem | 936/1181 (79.3) | 82/120 (68.3) | 0.85 (0.75–0.98) | 0.02 |
| Constipation | 871/1181 (73.8) | 65/123 (52.9) | 0.72 (0.60–0.87) | <0.001 |
| Reflux | 214/793 (27.0) | 44/110 (40.0) | 1.41 (1.03–1.92) | 0.03 |
| Respiratory | ||||
| Hyperventilation | 639/1175 (54.4) | 15/109 (13.8) | 0.26 (0.16–0.41) | <0.001 |
| Breath-holding | 724/1176 (61.6) | 26/109 (23.9) | 0.40 (0.28–0.57) | <0.001 |
| Sleep | ||||
| Night wakingb | 422/591 (71.4) | 96/110 (87.3) | 1.18 (1.1–1.31) | 0.03 |
| Night screaming | 483/1139 (42.4) | 60/118 (50.9) | 1.1 (0.86–1.32) | 0.57 |
| Night laughing | 774/1139 (68.0) | 70/122 (57.4) | 0.76 (0.64–0.90) | 0.001 |
Each individual in the AussieRett database could have contributed from one to six observations according to their participation in the initial and follow-up questionnaires, which accounts for the large number of total observation (Rett syndrome)
RR risk ratio; CI confidence interval
aAverage prevalence for the 6 time points
bData for females with night waking (Rett syndrome) was only available from 2009 and 2011 questionnaires