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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Amyloid. 2015 Dec 24;23(1):8–16. doi: 10.3109/13506129.2015.1112782

Figure 2.

Figure 2

Dual-energy SPECT/CT imaging of 125I-RAGE VC1 and 99mTc-p5 in mice. In amyloid-free WT mice there was no specific uptake of either radiotracer in healthy organs. Radioactivity seen in the thyroid (T), stomach (St) and intestines (I) is associated with protein catabolism and hepatobilliary clearance, respectively. In mice with AA amyloidosis, both reagents were observed in the liver (L) and spleen (S), sites of significant amyloid in this mouse model. Imaging was 2 h post-injection iv of 5 μg (100 μCi) of 125I-RAGE VC1 and 5 μg (200 μCi) of 99mTc-p5.