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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Amyloid. 2015 Dec 24;23(1):8–16. doi: 10.3109/13506129.2015.1112782

Figure 3.

Figure 3

RAGE VC1 binds preferentially to systemic AA amyloid in vivo. Contrast enhanced SPECT/CT imaging at 2 h post-injection of 125I-RAGE VC1 in representative mice with systemic AA (A–D) and dual-energy SPECT/CT images of 125I-RAGE VC1 and 99mTc-p5 in a representative single mouse with AA (E & F). Radiolabeled 125I-RAGE (red) was observed in amyloid-laden liver (L) and spleen (S) of mice, with free radioiodide in the thyroid (T) and stomach (St). Three-dimensional image views (D) confirmed the hepatosplenic uptake of 125I-RAGE VC1. The distribution of 125I-RAGE VC1 in AA mice was consistent with that of the amyloid-reactive peptide 99mTc-p5 in AA mice (E–F). Image views: A, axial; B, E and F, coronal; C, sagittal; and D, 3D representation.