Table 1.

Binding of ¹²⁵I-RAGE VC1 and peptide ¹²⁵I-p5 to rVλ6 Wil fibrils in the presence of RAGE ligands.

Inhibitors (concentration)	Solution	125I-RAGE VC1 bound*	125I-p5 bound*
No inhibitor	PBS	100.0	100.0
AGE-BSA (100 μM)	PBS	31.1	13.3
AGE-BSA (4 μM)	PBS	99.1	95.5
BSA (100 μM)	PBS	99.8	72.8
BSA (4 μM)	PBS	96.2	96.4
Enoxaparin™ (100 μM)	PBS	94.0	87.4
Enoxaparin™ (4 μM)	PBS	102.5	97.6
No inhibitor	TBS with 1 mM CaCl2	101.7	76.5
S100B (1 μM)	TBS with 1 mM CaCl2	97.2	80.2

^*% bound relative to no inhibitor. Measurements represent the mean of duplicate experiments.