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Histological sections of segmental defects treated with 5.5 μg of rhBMP-2 and external fixators of different stiffnesses. After 8 weeks, femora were harvested, decalcified, and embedded in paraffin. Sections were stained with safranin O-fast green. Scale bar = 1 mm. VeryLow = very-low-stiffness fixator (25.4 N/mm), Low = low-stiffness fixator (114 N/mm), Medium = medium-stiffness fixator (185 N/mm), and High = high-stiffness fixator (254 N/mm).
