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Histological sections of segmental defects 3 days after implantation of 5.5 μg of rhBMP-2. The defects were stabilized with an external fixator of very low (25.4-N/mm) or medium (185-N/mm) stiffness. After 3 days, the femora were harvested, decalcified, and embedded in paraffin. Sections were stained with safranin O-fast green. Scale bar = 1 mm.
