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. 2014 Jul 8;6(1):100–107. doi: 10.1136/heartasia-2013-010482

Table 2.

Exposure data from rats treated at low dose treatment regimen. Results obtained from black and white fur are reported separately

Dose* Exposure
(black fur)
Exposure (white fur)
Rat number mg/kg/day (mean) Cocaine (ng/mg) BE (ng/mg) Cocaine (ng/mg) BE (ng/mg)
W654 20.66 4.008 1.086 0.231 0.508
V654 26.84 0.474 0.481 Out Out
K207 18.90 0.982 0.375 0.218 0.360
P214 13.08 0.534 0.287 0.290 0.334
R206 18.16 3.446 0.951 0.160 0.313
T206 22.50 0.833 0.437 0.187 0.480
K206 11.16 1.280 0.380 0.108 0.259
M206 18.33 0.648 0.303 0.152 0.305
H206 13.17 1.139 0.398 0.129 0.671
I206 16.00 0.645 0.232 0.172 0.954
W206 16.17 Out Out 0.218 0.393
Mean 17.72 1.399 0.493 0.186 0.458
SD 4.55 1.261 0.288 0.054 0.213

Ecgonine methylester is not reported, as not measurable in most of the samples.

*Assuming 300 g of rat body weight.

BE, benzoylecgonine; Out, outlier.