Table 3.
Exposure data from rats treated at high dose treatment regimen
| Dose* | Exposure (white fur) |
|||
|---|---|---|---|---|
| Rat number | mg/kg/day (mean) | Cocaine (ng/mg) | BE (ng/mg) | EME (ng/mg) |
| M426 | 135.26 | 2.29 | 0.87 | 0.65 |
| C426 | 161.05 | 2.93 | 1.22 | 1.26 |
| I426 | 65.43 | 70.31 | 10.62 | 1.72 |
| U426 | 82.32 | 2.82 | 1.32 | 0.60 |
| O426 | 118.75 | 86.62 | 53.93 | 2.59 |
| S426 | 114.60 | 96.04 | 21.92 | 2.65 |
| R426 | 129.37 | 72.56 | 9.01 | 1.46 |
| AA426 | 112.13 | 4.93 | 1.08 | 0.88 |
| V426 | 105.92 | 1.93 | 1.27 | 0.82 |
| W426 | 81.00 | 2.83 | 1.09 | 0.79 |
| AC426 | 115.61 | 2.97 | 0.98 | 0.57 |
| Y426 | 112.15 | 2.85 | 1.28 | 0.90 |
| H426 | 100.15 | 28.35 | 4.63 | 2.07 |
| B426 | 106.80 | 4.06 | 2.07 | 0.96 |
| L426 | 136.76 | 1.99 | 0.91 | 0.64 |
| D426 | 102.17 | 8.33 | 2.73 | 1.07 |
| N426 | 112.27 | 9.56 | 3.09 | 0.98 |
| K426 | 134.35 | 3.15 | 0.69 | NM |
| Mean | 112.56 | 22.47 | 6.59 | 1.21 |
| SD | 22.66 | 33.35 | 12.96 | 0.67 |
White fur only was considered.
*Assuming 300 g of rat body weight.
BE, benzoylecgonine; EME, ecgonine methylester; NM, not measured.