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. 2016 Feb 9;107(4):469–477. doi: 10.1111/cas.12883

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Reduced expression of GANP is significantly associated with the degree of malignancy in breast cancers. (A) Representative images of GANP immunostaining of a normal mammary gland, ductal carcinoma in situ and invasive ductal carcinoma. Images at higher magnification are shown in the insets. Scale bar = 100 μm. (B) GANP expression in terminal duct lobular units. Representative images of GANP immunostaining are shown. Scale bar = 200 μm. (C) A comparison of GANP expression among the four groups is shown by immunohistochemistry (IHC) scores using box plots with whiskers defining the range of scores. LN, lymph node.