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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Cerebellum. 2015 Jun;14(3):292–307. doi: 10.1007/s12311-014-0640-x

Figure 9. Genetic mapping of the tippy locus.

Figure 9

A–C, To ascertain the tippy gene, an intersubspecific intercross between tip/+ heterozygous mice and Molf/Ei mice was performed (A). DNA from affected F2 mice was typed for polymorphic markers, localizing the tippy locus to a 1.0 cM/2.1 Mb region on distal chromosome 9 between SNP markers rs33627650 and rs3714504 (B, labeled in red). Haplotype analysis of 211 affected F2 mice defining the maximal critical interval harboring the tippy gene on chromosome 9 (C). Haplotypes for each marker are shown as columns with numbers of mice represented underneath. White boxes indicate C3H homozygous loci, white striped boxes indicate B6/C3H heterozygous loci, black striped boxes indicate B6 homozygous loci, and black boxes denote C3H or B6/Molf heterozygous loci.