Table 4.
Association of PTEN polymorphisms with the risk of HCC stratified by HBV genotypes
| SNP | HBV genotype B | HBV genotype C | ||||
|---|---|---|---|---|---|---|
| Non-HCC, n | HCC, n | AOR (95% CI) | Non-HCC, n | HCC, n | AOR (95% CI) | |
| rs1234220 | ||||||
| TT | 164 | 74 | 1.00 | 412 | 416 | 1.00 |
| CT | 37 | 32 | 2.02 (1.14–3.59) | 95 | 124 | 1.24 (0.91–1.71) |
| CC | 0 | 0 | – | 8 | 4 | 0.55 (0.15–1.99) |
| C (CT + CC) | 37 | 32 | 2.02 (1.14–3.59) | 103 | 128 | 1.20 (0.88–1.63) |
| rs2299939 | ||||||
| GG | 124 | 67 | 1.00 | 303 | 337 | 1.00 |
| GT | 72 | 36 | 0.88 (0.53–1.48) | 202 | 175 | 0.78 (0.60–1.02) |
| TT | 8 | 3 | 0.67 (0.17–2.73) | 18 | 27 | 1.51 (0.79–2.90) |
| T (GT + TT) | 80 | 39 | 0.86 (0.52–1.43) | 220 | 202 | 0.84 (0.65–1.08) |
| rs1234213 | ||||||
| CC | 49 | 31 | 1.00 | 132 | 132 | 1.00 |
| CT | 109 | 47 | 0.67 (0.37–1.21) | 266 | 272 | 1.01 (0.74–1.38) |
| TT | 47 | 28 | 0.91 (0.46–1.78) | 129 | 132 | 1.10 (0.76–1.59) |
| T (CT + TT) | 156 | 75 | 0.75 (0.43–1.29) | 395 | 409 | 1.04 (0.78–1.39) |
AOR: Adjusted odds ratio (adjusted for age and gender); CI: Confidence interval; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; Non-HCC: ASC + CHB + LC; PTEN: Phosphatase and tensin homolog; SNP: Single nucleotide polymorphism; ASC: Asymptomatic hepatitis B surface antigen carrier; CHB: Chronic hepatitis B; LC: Liver cirrhosis.