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. 2015 Apr 20;128(8):1114–1120. doi: 10.4103/0366-6999.155119

Figure 3.

Figure 3

Effects of tongxinluo (TXL) on the hypoxia-induced protein content changes. (a) The protein contents of cyclooxygenase-2 (COX-2), prostacyclin synthase (PGIS), inducible nitric oxide synthase (iNOS), endothelial NOS, hypoxia-inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor (VEGF) were detected by Western blotting; (b) TXL decreased the hypoxia-induced COX-2, with increase of PGIS; (c) TXL decreased the hypoxia-induced iNOS; (d) TXL decreased the hypoxia-induced HIF-1α, HIF-2α, and VEGF. *P < 0.05 or P < 0.01, compared with control (Con) group; P < 0.05 or §P < 0.01, compared with hypoxia group. The data were repeated twice and represented as mean ± standard division. LT: Low dose TXL; MT: Middle dose TXL; HT: High-dose TXL.