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. Author manuscript; available in PMC: 2016 Aug 15.
Published in final edited form as: Cancer Res. 2015 Jun 29;75(16):3255–3267. doi: 10.1158/0008-5472.CAN-15-0325

Figure 2.

Figure 2

Rational design of PEG-NR treatment regimens to enhance drug delivery and efficacy. (a) Accumulation of doxorubicin liposomes in unheated, single heat exposure (1X heat), and re-exposure with delta T of 24 h (2X heat) groups. Bars normalized to unheated controls. (n = 5 mice per group, *P<0.05, Mann-Whitney test.) Error bars, SE. (b) Time courses for each experimental group. Animals received 0, 1, or 2 exposures to PEG-NR heating with doxorubicin liposomes administered with the final heat exposure. Regimens were repeated weekly for the duration of the therapeutic trial period. (c-d) Tumor volume and Kaplan-Meier survival analysis (n = 8–9 mice per group, *P<0.05, (c) unpaired t-test, two-tailed, Holm-Sidak method for multiple comparisons and (d) Log-rank Mantel-Cox test) Error bars, SE.