TABLE 1. Model Parameters with Initial Ranges and Final Estimates as Presented by Nordberg and Kjellstrom (1979).
| Name | Unit | Initially assumed range | Final estimate | |
|---|---|---|---|---|
| Minimum | Maximum | |||
| C7 | unitlessa | 0.2 | 0.4 | 0.25 |
| C9 | unitlessa | 0.4 | 0.8 | 0.44 |
| C10 | day−1 | 0.00004 | 0.0002 | 0.00014 |
| C11 | unitlessa | 0.05 | 0.5 | 0.27 |
| C12 | unitlessa | 0.1 | 0.4 | 0.25 |
| C13 | day−1 | 0 | 0.0001 | 0.00003 |
| C14 | day−1 | 0.0001 | 0.0003 | 0.00016 |
| C15 | day−1 | 0 | 0.0001 | 0.00005 |
| C16 | day−1 | 0.004 | 0.015 | 0.012 |
| C17 | unitlessa | 0.8 | 0.98 | 0.95b |
| C18 | day−1 | 0 | 0.0001 | 0.00001 |
| C19 | day−1 | 0.00002 | 0.0002 | 0.00014c |
| CX | unitlessa | 0.01 | 0.05 | 0.04 |
| C20 | unitlessa | 0.05 | 0.5 | 0.1 |
| C21 | day−1 | 0 | 0.000002 | 0.0000011 |
Abbreviations: C7, fraction from systemic uptake to plasma metallothionein; C9, fraction from other plasma to other tissue; C10, transfer rate from other tissue to other plasma; C11, fraction from other plasma to fecal excretion; C12, fraction from other plasma to liver; C13, transfer rate from liver to other plasma; C14, transfer rate from liver to plasma metallothionein; C15, excretion rate from liver to feces; C16, transfer rate from red blood cells to plasma metallothionein; C17, tubular reabsorptive capacity; C18, transfer rate from kidney to other plasma; C19, excretion rate of Cd accumulated in kidney to 24-h urine; CX, fraction from other plasma to red blood cells; C20, fraction of Cd in the plasma compartments contributing to whole blood; C21, decrease in C19.
aUnitless fraction, allowed range 0–1.
bC17 is assumed to decrease linearly from 0.95 at age 30 to 0.64 at age 80.
cC19 is assumed to increase by C21 per year, starting at age 30.