Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Plasma exposure after 4-week oral dosing with compound 1 to rat and dog. AUC was determined after a single dose (D1, AUCinf) and after at the end of the treatment (D28, AUC0–24 h) for compound 1 (A), carboxylic metabolite (compound 2, B), and β-hydroxylated metabolite (compound 3, C). Exposure values are means ± SD of three males and three females for rats, and 4–6 males and 4–6 females for dog, with genders combined.
