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. 2014 Oct 2;141(2):353–364. doi: 10.1093/toxsci/kfu131

FIG. 4.

FIG. 4.

Liver microsomal CYP marker activities after 4-week oral dosing with compound 1. Marker activities in rat (A) include PROD (CYP2B1/2, solid bars), 2α-OHT (CYP2C11, open bars), and 6β-OHT (CYP3A1/2, hatched bars). Marker activities in dog (B) include EROD (CYP1A1/2, open bars), BROD (CYP2B11, solid bars), and 6β-OHT (CYP3A12, hatched bars). Activities were compared with those in control animals. Results are means (+SD) of six males and six females for rat, and four males and four females for dog, with genders combined. Pooled dog liver microsomes were also analyzed for CYP2B content by Western blotting (insert; c: controls).