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Hepatic levels of total porphyrin (A) and ferrochelatase activity (B) after 4-week oral dosing with compound 1. Results are means (+SD) of six male and six female rats (open bars) or four male and four female dogs (solid bars), with genders combined. Treated animals are from the top dose groups (1000 and 200 mg/kg/day for rats and dogs, respectively).
