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. 2014 Oct 2;141(2):353–364. doi: 10.1093/toxsci/kfu131

FIG. 9.

FIG. 9.

In vitro induction of CYP marker activities in hepatocytes incubated with compound 1. Marker activities in dog hepatocytes (A) include EROD (CYP1A1/2, open bars), BROD (CYP2B11, solid bars), and 6β-OHT (CYP3A12, hatched bars). Marker activities in human hepatocytes (B) include EROD (CYP1A1/2, open bars), bupropion hydrolase (CYP2B6, solid bars), and midazolam 1′-hydroxylase (CYP3A4, hatched bars). Activities were compared with those in vehicle-treated cells. Results are means (+SD) of three wells. The positive control omeprazole produced a 20- and a 10-fold induction of CYP1A1 in dog and human hepatocytes, respectively. Phenobarbital produced a 51- and a 16-fold induction of CYP2B in dog and human hepatocytes, respectively. Finally, rifampicin produced a 5- and a 2.4-fold induction of CYP3A in dog and human hepatocytes, respectively.