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. 2015 Feb 10;145(1):90–97. doi: 10.1093/toxsci/kfv036

FIG. 2.

FIG. 2.

Vitamin D3 protects against LPS-induced skeletal malformations. All pregnant mice except controls were ip injected with LPS (25 μg/kg) daily from GD8 to GD12. In LPS+VitD3 group, pregnant mice were pretreated with vitamin D3 (25 μg/kg) by gavage daily 2 days before LPS injection. All pregnant mice were sacrificed on GD 18. Live fetuses were examined for skeletal malformations. A, Supraoccipital bone scores: 1, well ossified; 5, completely unossified. B, The incidence of fetus with sternum malformations. C, The incidence of fetus with rib malformations. Data were presented as means ± SEM *P < .05, **P < .01.