Table 2.
Meta-analysis of the association between IL-10-592 C > A polymorphism and T2DM.
| Comparison | Population | Sample size |
No. of studies | Test of association |
Test of heterogeneity |
Publication bias |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T2DM | Control | OR | 95% CI | P-value | Model | Q test | P-value | I2 (%) | P-value (Egger's) | |||
| A allele versus C allele (allelic contrast) |
Overall | 5842 | 6632 | 10 | 0.901 | 0.700–1.161 | 0.421 | R | 69.82 | < 0.001 | 87.11 | 0.188 |
| Asian | 2802 | 2702 | 6 | 0.859 | 0.565–1.304 | 0.475 | R | 54.90 | < 0.001 | 90.89 | 0.398 | |
| European | 1164 | 2340 | 2 | 0.946 | 0.805–1.113 | 0.504 | F | 0.161 | 0.688 | 0.0 | NA | |
| African | 1834 | 1496 | 1 | 1.332 | 1.145–1.550 | < 0.001 | F | 0.0 | 1.0 | 0.0 | NA | |
| AC + AA versus CC (dominant model) |
Overall | 2921 | 3316 | 10 | 1.106 | 0.967–1.265 | 0.140 | R | 52.37 | < 0.001 | 82.81 | 0.08 |
| Asian | 1401 | 1351 | 6 | 0.725 | 0.410–1.283 | 0.270 | R | 39.67 | < 0.001 | 87.40 | 0.289 | |
| European | 582 | 1170 | 2 | 0.980 | 0.802–1.196 | 0.840 | F | 0.227 | 0.634 | 0.0 | NA | |
| African | 917 | 748 | 1 | 1.352 | 1.114–1.641 | 0.002 | F | 0.0 | 1.0 | 0.0 | NA | |
| AA versus CC + AC (recessive model) |
Overall | 2921 | 3316 | 10 | 1.225 | 0.940–1.596 | 0.134 | R | 46.68 | < 0.001 | 80.72 | 0.935 |
| Asian | 1401 | 1351 | 6 | 0.945 | 0.466–1.917 | 0.876 | R | 34.85 | < 0.001 | 85.65 | 0.998 | |
| European | 582 | 1170 | 2 | 0.719 | 0.450–1.149 | 0.168 | F | 0.016 | 0.900 | 0.0 | NA | |
| African | 917 | 748 | 1 | 1.764 | 1.228–2.536 | 0.002 | F | 0.0 | 1.0 | 0.0 | NA | |
| AC versus CC (heterozygote contrast) |
Overall | 2533 | 3010 | 10 | 1.074 | 0.936–1.232 | 0.310 | R | 35.47 | < 0.001 | 74.62 | 0.053 |
| Asian | 1136 | 1161 | 6 | 0.760 | 0.471–1.227 | 0.261 | R | 25.47 | < 0.001 | 80.37 | 0.291 | |
| European | 557 | 1101 | 2 | 1.017 | 0.828–1.250 | 0.871 | F | 0.230 | 0.632 | 0.0 | NA | |
| African | 820 | 701 | 1 | 1.257 | 1.026–1.540 | 0.027 | F | 0.0 | 1.0 | 0.0 | NA | |
| AA versus CC (homozygote contrast) |
Overall | 1630 | 1877 | 10 | 1.297 | 0.979–1.718 | 0.070 | R | 59.05 | < 0.001 | 84.76 | 0.462 |
| Asian | 753 | 711 | 6 | 0.806 | 0.298–2.181 | 0.671 | R | 47.01 | < 0.001 | 89.36 | 0.556 | |
| European | 343 | 703 | 2 | 0.725 | 0.450–1.168 | 0.186 | F | 0.044 | 0.835 | 0.0 | NA | |
| African | 522 | 450 | 1 | 1.957 | 1.346–2.845 | < 0.001 | F | 0.0 | 1.0 | 0.0 | NA | |
| AC versus CC + AA (overdominant model) |
Overall | 2921 | 3316 | 10 | 1.035 | 0.912–1.174 | 0.598 | R | 21.66 | 0.010 | 58.45 | 0.018 |
| Asian | 1401 | 1351 | 6 | 0.888 | 0.659–1.196 | 0.433 | R | 13.99 | 0.016 | 64.28 | 0.170 | |
| European | 582 | 1170 | 2 | 1.045 | 0.854–1.280 | 0.667 | F | 0.207 | 0.649 | 0.0 | NA | |
| African | 917 | 748 | 1 | 1.143 | 0.939–1.390 | 0.183 | F | 0.0 | 1.0 | 0.0 | NA | |