TABLE 3. Effects on Steroid Hormone Production in Exposed H295R Cells.

	BPA		BPB		BPC1		BPC2		Vinclozolin		Butyl paraben		Atrazine
	LOECa (μM)	Maxb change	LOEC (μM)	Max change	LOEC (μM)	Max change	LOEC (μM)	Max change	LOEC (μM)	Max change	LOEC (μM)	Max change	LOEC (μM)	Max change
Pregnenolone	10	1.76	10	1.97	10	1.70	3	0.38	NE	—	30	2.46	10	1.40
17α-OH-pregnenolone	Eq.c	—	NE	—	0.1	0.25	0.3	0.17	NE	—	NE	—	NE	—
Progesterone	30	1.80	3	2.41	0.3	6.35	10	1.30	3	0.66	10	3.72	1	2.01
17α-OH-progesterone	3	0.71	1	1.69	0.3	5.98	Eq.	—	3	0.53	1	4.39	0.3	1.83
DHEA	Eq.	—	10	0.56	1	0.15	Eq.	—	Eq.	—	NE	—	NE	—
Androstenedione	0.03	0.09	3	0.19	10	0.13	3	0.09	10	0.72	30	0.23	NE	—
Testosterone	0.1	0.08	3	0.16	Eq.	—	0.1	0.10	3	0.70	3	0.23	10	1.19
Estrone	NEd	—	1	1.34	NE	—	NE	—	NE	—	NE	—	NE	—
Estradiol	10	1.56	NE	—	10	1.86	10	1.86	10	1.99	3e	1.60e	1e	4.70e
11-Deoxycorticosterone	NE	—	30	0.82	3	0.15	1	0.39	3	0.49	Eq.	—	0.3	1.87
11-Deoxycortisol	10	0.23	3	0.36	10	0.04	0.30	0.14	1	0.53	30	0.19	3	1.35
Corticosterone	Eq.	—	Eq.	—	10	0.32	Eq.	—	NE	—	30	0.20	10	1.34
Cortisol	10	0.32	10	0.29	1	0.04	3	0.20	NE	—	NE	—	NE	—

^aLowest observed effective concentration (LOEC in μM), which is defined as the lowest concentration statistically significant different (p < 0.05) from the solvent control average.

^bMaximum fold change (up or down) of the average response observed at any concentration significantly different from the average solvent control level.

^cEquivocal results.

^dNE: no effect observed at the highest noncytotoxic concentration tested.

^eEstradiol levels were analyzed by enzyme-linked immunosorbant assay according to the manufacturer's protocol.