TABLE 4. Multivariable-adjusted Linear Regression Analysis of the Associations Between Children's Urinary Arsenic Concentrations (μg/l) in Tertiles and Plasma Cytokines (pg/ml) in Children at 4.5 Years of Age.
| Cytokines (pg/ml) | Tertiles of U-As (μg/l); range (median) | ||
|---|---|---|---|
| 12–44 (28), reference | 45–106 (71) | 107–1228 (203) | |
| β (95% CI)a | β (95% CI)a | β (95% CI)a | |
| IL-2 (pg/ml) | 0 | −0.54 (−1.52, 0.43) | −1.57 (−2.56, −0.57) |
| TNF-α (pg/ml) | 0 | −0.65 (−4.64, 3.34) | −4.53 (−8.62, −0.42) |
| IL-12 (pg/ml) | 0 | −5.21 (−12.31, 1.89) | −5.16 (−12.51, 2.19) |
| IL-2/IL-4 | 0 | −.17 (−0.43, 0.08) | −0.44 (−0.71, −0.17) |
| IL-2/IL-10 | 0 | −.08 (−0.20, 0.05) | −0.15 (−0.28, −0.02) |
| IL-2/IL-13 | 0 | −.03 (−0.12, 0.06) | −0.11 (−0.19, −0.01) |
| TNF-α/IL-4 | 0 | −.52 (−1.46, 0.43) | −1.03 (−2.01, −0.06) |
| TNF-α/IL-10 | 0 | −0.91 (−2.54, 0.73) | −1.16 (−2.84, 0.54) |
| TNF-α/IL-13 | 0 | −0.06 (−0.56, 0.44) | −0.43 (−0.94, 0.08) |
Note: U-As, sum of urinary arsenic metabolites; β, regression co-efficient; CI, confidence interval; IL-2, interleukin 2; TNF-α, tumor necrosis factor-α; IL-12, interleukin 12; IL-4, interleukin 4; IL-10, interleukin 10; IL-13, interleukin 13.
aAdjusted for age, gender, and SES.