Table 3. Functional and cognitive status of centenarians’ offspring (CO) and offspring of non-long-lived parents (NCO).
| N | CO | N | NCO | OR (95% CI) | p-value | |
|---|---|---|---|---|---|---|
| Past diseases | ||||||
| Pneumonia, n (%) | 267 | 65 (24.3) | 106 | 22 (20.8) | 1.277 (0.723 - 2.254) | 0.400 |
| Myocardial Infarction, n (%) | 267 | 12 (4.5) | 106 | 12 (11.3) | 0.489 (0.201 - 1.194) | 0.116 |
| Stroke, cerebral thrombosis-haemorrhage, n (%) | 266 | 4 (1.5) | 105 | 8 (7.6) | 0.200 (0.051 - 0.789) | 0.022 |
| Malign tumor, n (%) | 267 | 26 (9.7) | 106 | 18 (17.0) | 0.533 (0.269 - 1.056) | 0.071 |
| Benign tumor, n (%) | 267 | 11 (4.1) | 106 | 10 (9.4) | 0.419 (0.162 - 1.083) | 0.072 |
| Hip fracture, n (%) | 267 | 5 (1.9) | 106 | 4 (3.8) | 0.535 (0.136 - 2.113) | 0.372 |
| Spinal collapse, n (%) | 267 | 8 (3.0) | 106 | 6 (5.7) | 0.404 (0.122 - 1.336) | 0.137 |
| Current diseases | ||||||
| Heart failure, n (%) | 267 | 2 (0.7) | 106 | 4 (3.8) | 0.276 (0.047 - 1.611) | 0.153 |
| Irregular heart rhythm, n (%) | 267 | 29 (10.9) | 107 | 20 (18.7) | 0.584 (0.301 - 1.131) | 0.110 |
| Hypertension, n (%) | 267 | 109 (40.8) | 107 | 68 (63.6) | 0.485 (0.288 - 0.816) | 0.006 |
| COPD, n (%) | 267 | 9 (3.4) | 106 | 9 (8.5) | 0.394 (0.143 - 1.089) | 0.073 |
| Dementia, n (%) | 267 | 0 (0.0) | 106 | 1 (0.9) | na | na |
| Depression/Anxiety, n (%) | 267 | 41 (15.4) | 106 | 22 (20.8) | 0.669 (0.362 - 1.239) | 0.201 |
| Osteoporosis, n (%) | 267 | 44 (16.5) | 106 | 24 (22.6) | 0.520 (0.270 - 1.002) | 0.051 |
| Diabetes, n (%) | 267 | 26 (9.7) | 106 | 12 (11.3) | 1.042 (0.462 - 2.352) | 0.921 |
| Hypothyroidism, n (%) | 267 | 25 (9.4) | 106 | 8 (7.5) | 0.988 (0.400 - 2.437) | 0.979 |
| Hyperthyroidism, n (%) | 267 | 3 (1.1) | 106 | 4 (3.8) | 0.290 (0.053 - 1.593) | 0.154 |
| Hypercholesterolemia, n (%) | 267 | 91 (34.1) | 106 | 46 (43.4) | 0.563 (0.342 - 0.929) | 0.025 |
| Chronic renal insufficiency, n (%) | 267 | 3 (1.1) | 106 | 5 (4.7) | 0.273 (0.052 - 1.423) | 0.123 |
| aOther diseases, n (%) | 265 | 85 (32.1) | 107 | 53 (49.5) | 0.484 (0.296 - 0.793) | 0.004 |
| Drugs use, n (%) | ||||||
| 0 drugs, n (%) | 267 | 58 (21.7) | 106 | 7 (6.6) | 1 | |
| 1-3 drugs, n (%) | 267 | 148 (55.4) | 106 | 48 (45.3) | 0.375 (0.156 - 0.897) | 0.028 |
| 4 or more drugs, n (%) | 267 | 61 (22.8) | 106 | 51 (48.1) | 0.136 (0.053 - 0.347) | <0.001 |
| Cardiovascular Therapy, n (%) | 267 | 54 (20.2) | 106 | 36 (34.0) | 0.493 (0.299 - 0.813) | 0.005 |
| Hypotensive Therapy, n (%) | 267 | 106 (39.7) | 106 | 68 (64.2) | 0.368 (0.231 - 0.587) | <0.001 |
| Antidiabetic Therapy, n (%) | 267 | 15 (5.6) | 106 | 10 (9.4) | 0.571 (0.248 - 1.316) | 0.188 |
| Lipid-lowering Therapy, n (%) | 267 | 47 (17.6) | 106 | 40 (37.7) | 0.353 (0.213 - 0.583) | <0.001 |
Prevalence of past and current diseases was adjusted for age, gender, education, marital status and BMI.
a
The following conditions are included: prostatic hypertrophy, cataract and glaucoma, gastritis, hiatus hernia, cholelithiasis, allergies, hemicranias, haemorrhoids, etc. na: not assessed.