Table 4. Functional and cognitive status of centenarians’ offspring (CO) and offspring of non-long-lived parents (NCO).

	CO N=266	NCO N=105	p-value
Conventional Risk Factors
Total cholesterol, mg/dl	203.0 (177.0 – 231.0)	195.0 (171.5 – 217.0)	0.037
LDL cholesterol, mg/dl	119.3 (98.2 – 150.0)	112.0 (88.0 – 135.6)	0.003
HDL cholesterol, mg/dl	51.0 (42.0 – 63.0)	56.0 (45.5 – 74.0)	0.019
Total/HDL cholesterol ratio	4.0 (3.1 – 4.8)	3.4 (2.7 – 4.2)	0.001
Triglycerides, mg/dl	111.5 (86.0 – 156.0)	104.5 (79.0 – 146.0)	0.175
Albumin, mg/dl	4.2 (3.4 – 4.5)	4.1 (3.4 – 4.4)	0.445
CRP, mg/L	1.3 (0.8 – 3.0)	1.6 (0.8 – 3.2)	0.341
A-SAA protein, mg/ml	92.0 (44.9 – 197.3)	85.3 (50.7 – 177.7)	0.959
IL-6, pg/ml	16.7 (10.0 – 34.0)	19.1 (10.9 – 31.4)	0.500
Metabolic mediators
Adiponectin, μg/ml	34.0 (19.3 – 56.3)	30.6 (18.3 – 56.4)	0.496
Leptin, ng/ml	14.3 (7.3 – 31.8)	14.3 (6.7 – 32.4)	0.991
Resistin, ng/ml	9.2 (7.0 – 12.2)	9.1 (7.0 – 12.4)	0.964
TNF-α, pg/ml	10.3 (2.8 – 31.9)	11.0 (3.8 – 31.5)	0.655
Insulin resistance markers
Glycaemia, mmol/L	4.8 (4.4 – 5.4)	4.9 (4.6 – 5.5)	0.095
Insulin, μIUg/ml	10.4 (6.2 – 14.9)	10.5 (6.9 – 14.1)	0.704
HOMA-IR index	2.2 (1.3 – 3.5)	2.5 (1.5 – 3.6)	0.393
aThyroid Hormones
Free triiodothyronine (FT3), pg/ml	3.0 (2.8 – 3.3)	3.0 (2.8 – 3.3)	0.922
Free thyroxin (FT4), ng/ml	11.5 (10.4 – 12.6)	11.9 (10.9 – 12.8)	0.033
TSH, mIU/ml	1.8 (1.3 – 2.5)	1.8 (1.3 – 2.4)	0.798
T3/T4 ratio	0.3 (0.2 – 0.3)	0.3 (0.2 – 0.3)	0.101

^aSubjects under thyroid therapy were excluded from the analysis. Data are expressed as median (min-max) between parenthesis.

p-value was derived from Mann-Whitney test.