Table 2.
Allelic and genotype frequency of the SNPs under investigation in Chinese SLE patients (n = 189)
| Gene | SNP | Genotype | Frequency (%) | Allele | Frequency (%) |
|---|---|---|---|---|---|
| CYP2B6 | −2320 T > C | TT | 27 (14.3) | T | 142 (37.6) |
| CT | 88 (46.6) | C | 236 (62.4) | ||
| CC | 74 (39.2) | ||||
| −750 T > C | TT | 48 (25.4) | T | 166 (43.9) | |
| CT | 70 (37.0) | C | 212 (56.0) | ||
| CC | 71 (37.6) | ||||
| 64C > T | CC | 180 (95.2) | C | 369 (97.6) | |
| CT | 9 (4.8) | T | 9 (2.4) | ||
| TT | 0 | ||||
| 516G > T | GG | 106 (56.1) | G | 281 (74.3) | |
| GT | 69 (36.5) | T | 97 (25.6) | ||
| TT | 14 (7.4) | ||||
| 15582C > T | CC | 34 (18.0) | C | 160 (42.3) | |
| CT | 92 (48.7) | T | 218 (57.7) | ||
| TT | 63 (33.3) | ||||
| 785A > G | AA | 95 (50.3) | A | 253 (66.9) | |
| AG | 63 (33.3) | G | 125 (33.0) | ||
| GG | 31 (16.4) | ||||
| 1459C > T | CC | 189 (100) | C | 378 (100) | |
| CT | 0 | T | 0 | ||
| TT | 0 | ||||
| CYP2C19 | *2 | *1*1 | 97 (51.3) | *1 | 260 (68.8) |
| *1*2 | 66 (34.9) | *2 | 118 (31.2) | ||
| *2*2 | 26 (13.8) | ||||
| *3 | *1*1 | 165 (87.3) | *1 | 354 (93.7) | |
| *1*3 | 24 (12.7) | *3 | 24 (6.3) | ||
| *3*3 | 0 | ||||
| *17 | *1*1 | 189 (100) | *1 | 378 (100) | |
| *1*17 | 0 | *17 | 0 | ||
| *17*17 | 0 | ||||
| GSTP1 | IIe/Val | I/I | 130 (68.8) | I | 316 (83.6) |
| I/V | 56 (30.7) | V | 62 (16.4) | ||
| VV | 3 (2.6) | ||||
| GSTM1 | + | 66 (46.8) | |||
| − | 75 (53.2) | ||||
| GSTT1 | + | 56 (39.7) | |||
| − | 85 (60.3) | ||||
| PXR | −25 913 C > T | TT | 117 (61.9) | T | 289 (76.5) |
| (rs1523130) | TC | 55 (29.1) | C | 89 (23.5) | |
| CC | 17 (9.0) | ||||
| −25385C > T | CC | 120 (63.5) | C | 292 (77.2) | |
| (rs3814055) | CT | 52 (27.5) | T | 86 (22.8) | |
| TT | 17 (9.0) | ||||
| −4356 T > C | TT | 29 (15.3) | T | 150 (39.7) | |
| (rs13059232) | TC | 92 (48.7) | C | 228 (60.3) | |
| CC | 68 (36.0) | ||||
| 579A > G | AA | 61 (32.3) | A | 201 (53.2) | |
| (rs7643645) | AG | 79 (41.8) | G | 177 (46.8) | |
| GG | 49 (25.9) |