Table 5.

Adverse events occurring more than once during the study

	Normal renal function (n = 25)	Mild renal impairment (n = 12)	Moderate renal impairment (n = 12)	Total (n = 49)
Adverse events	F, n, %	F, n, %	F, n, %	F, n, %
Total	29, 15, 60.0	25, 8, 66.7	2, 2, 16.7	56, 25, 51.0
Headache	8, 4, 16%	6, 5, 42%	‐	14, 9, 18%
Dizziness	‐	5, 4, 33%	1,1, 8%	6, 5, 10%
Diarrhoea	2, 2, 8%	‐	‐	2, 2, 4%
Dry mouth	2, 2, 8%	‐	‐	2, 2, 4%
Fatigue	4, 4, 16%	1, 1, 8%	‐	5, 5, 10%
Feeling hot	‐	2, 2, 17%	‐	2, 2, 4%
Nasopharyngitis	5, 5, 20%	1, 1, 8%	‐	6, 6, 12%
Tinnitus	‐	2, 1,8%	‐	2,1, 2%
Vertigo	‐	2, 2, 17%	‐	2, 2, 4%
Sleep disorder	1,1,4%	1,1,8%	‐	2,2,4%

F, Number of events; n, number of subjects; %, the percent of treated subjects